Publications

1. Höppner, J.; Firat, D.; Parvez-Khan, M.; Reyes, M.; Hanna, P.; Yadav, P. S.; Dean, T.; Ramos-Torres, K. M.; Brugarolas, P.; Collins, M. T.; Wein, M. N.; Liu, S., Gellman, S. H.; Schipani, E.; Kronenberg, H. M.; Gardella, T. J.; Jüppner, H. Proc. Natl. Acad. Sci. U.S.A. 2025, 122, e2500176122

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2. Liu, S.; Daley, E. J.; Tran, L. M. L., Yu, Z.; Reyes, M.; Dean, T.; Khatri, A.; Levine, P. M.; Balana, A.T.; Pratt, M. R.; Jupper, H., Gellman, S. H., Gardella, T. J. Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants. J. Am. Chem. Soc. 2024, 146, 6522-6529.

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3. Ongpipattanakul, C.#, Liu, S.#, Luo, Y. R.#, Nair, S. K., van der Donk, W. A. The Mechanism of Thia-Michael Addition Catalyzed by LanC Enzymes. Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2217523120 (Direct Submission, #equal contribution)

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4. Liu, S.#, Yu, Z.#, Daley, E. J.; Bingman, C. A.; Bruchs, A. T.; Gardella, T. J.; Gellman, S. H.Altered Signaling at the PTH Receptor via Modified Agonist Contacts with the Extracellular Domain Provides a Path to Prolonged Agonism In Vivo. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2212736119 (Direct Submission, #equal contribution)

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5. White, A. D.; Pena, K. A.; Clark, L. J.; Maria, C. S.; Liu, S.; Jean-Alphonse F. G.; Lee, J. Y.;Lei, S. F.; Cheng, Z; Tu, C. L.; Fang, F.; Szeto, N.; Gardella, T. J.; Xiao, K.; Gellman, S. H.; Bahar, I.; Sutkeviciute, I.; Chang, W; Vilardaga, J. P. Decoding location bias information of cAMP signaling in a class B GPCR. Sci. Signal. 2021, 14, eabc5944

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6. Lai, K. Y.; Galan. S.; Zeng, Y. B.; Zhou, H.; He, C.; Raj, R.; Riedl, J.; Liu, S.; Chooi, K. P.;Garg, N.; Zeng, M.; Jones, L. H.; Hutchings, G. J.; Mohammed, S.; Nair, S. K.; Chen, J.; Davis, B.G.; van der Donk, W. A., LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome. Cell 2021, 184, 2680–2695.

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7. Liu, S.; Gellman, S. H., Preparation of β2-Homologous Amino Acids Bearing Polar Side Chainsvia a Collective Synthesis Strategy. J. Org. Chem. 2020, 85, 1718-1724.

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8. White, A. D.; Jean-Alphonse, F. G.; Fang, F.; Pena, K. A.; Liu, S.; Konig, G. M.; Inoue, A.;Aslanoglou, D.; Gellman, S. H.; Kostenis, E.; Xiao, K. H.; Vilardaga, J. P., G(q/11)-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR. Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 7455-7460. (Direct Submission)

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9. Liu, S.; Jean-Alphonse, F. G.; White, A. D.; Wootten, D.; Sexton, P. M.; Gardella, T. J.;Vilardaga, J. P.; Gellman, S. H., Use of Backbone Modification to Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism. J. Am. Chem. Soc. 2019, 141, 14486-14490.

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10. Cheloha, R. W.; Woodham, A. W.; Bousbaine, D.; Wang, T.; Liu, S.; Sidney, J.; Sette, A.;Gellman, S. H.; Ploegh, H. L., Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids. J. Immunol. 2019, 203, 1619-1628.

11. Liu, S.; Cheloha, R. W.; Watanabe, T.; Gardella, T. J.; Gellman, S. H., Receptor selectivityfrom minimal backbone modification of a polypeptide agonist. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 12383-12388. (Direct Submission)